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震撼!南昌大学借 GEO 仅7图 斩获双一区!

  • 2026-03-25 23:35:18
震撼!南昌大学借 GEO 仅7图 斩获双一区!

震撼！南昌大学借 GEO 仅7图 斩获双一区！

研究背景
⚡食管鳞癌侵袭性强预后差☠️，肿瘤微环境免疫抑制是治疗瓶颈⛔，巨噬细胞胞葬作用的调控机制不明🔍，亟需挖掘新的靶向治疗通路🧬。

亮点
① 🧫发现 FN1 + 巨噬细胞高胞葬，促 ESCC 免疫抑制
② 🧬TP63 转录激活 RAC2，增强巨噬细胞胞葬能力
③ ⚖️该通路驱动巨噬细胞向 M2 型极化重编程
④ 🎯靶向此轴可抑制胞葬，显著抑制肿瘤生长

研究方法
🧪结合单细胞 RNA 测序、体外细胞功能实验🐀与体内动物模型验证，解析 TP63-RAC2 调控巨噬细胞胞葬的分子机制。

结语
📜本研究阐明 TP63-RAC2 介导胞葬的核心作用✨，为逆转食管鳞癌免疫抑制提供新靶点🎯，为癌症精准免疫治疗筑牢理论基础🧑‍🔬。

如果你也想用 GEO 进行生信分析，复刻高分思路,欢迎联系干货生信！#学术论文#论文发表#论文辅导#生信分析#图文分享#学术界新动态#科研热点追踪#食管鳞癌#肿瘤

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  140. /yingpanguazai/ssd/ssd1/www/a.460.net.cn/vendor/topthink/think-trace/src/Html.php ( 4.42 KB )
  1. CONNECT:[ UseTime:0.000686s ] mysql:host=127.0.0.1;port=3306;dbname=aa460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000703s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000286s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000297s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000437s ]
  6. SELECT * FROM `set` [ RunTime:0.000228s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000578s ]
  8. SELECT * FROM `article` WHERE `id` = 478866 LIMIT 1 [ RunTime:0.000367s ]
  9. UPDATE `article` SET `lasttime` = 1776555590 WHERE `id` = 478866 [ RunTime:0.001266s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000232s ]
  11. SELECT * FROM `article` WHERE `id` < 478866 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000495s ]
  12. SELECT * FROM `article` WHERE `id` > 478866 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000428s ]
  13. SELECT * FROM `article` WHERE `id` < 478866 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000731s ]
  14. SELECT * FROM `article` WHERE `id` < 478866 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.000605s ]
  15. SELECT * FROM `article` WHERE `id` < 478866 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.000761s ]
0.079578s