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微生物青年之声 | 南昌大学谭惠子研究员专访:膳食-肠道菌群互作与健康调控

  • 2026-06-30 11:22:15
微生物青年之声 | 南昌大学谭惠子研究员专访:膳食-肠道菌群互作与健康调控
｜Young Voices in Microbiome
｜微生物青年之声：

本期“微生物青年之声”特别篇聚焦膳食成分与肠道菌群的互作机制及其在精准营养干预中的应用前景。随着肠道菌群研究的深入，膳食组分作为连接饮食摄入、微生物群落动态变化与宿主健康状态的关键桥梁，正日益成为微生物组学与食品科学交叉领域的重要研究方向。在这一过程中，如何从分子层面解析不同膳食成分(如果胶、硫酸化多糖等) 对特定肠道菌群的靶向调节作用，并进一步发展面向个性化营养需求的精准调控策略，已成为当前相关领域的重要科学命题。

本期我们有幸邀请到期刊作者南昌大学谭惠子研究员。在本次访谈中，谭老师结合其长期从事肠道微生物及膳食组分调节健康的科研经历，回顾了从拟杆菌等低丰度肠道菌的分离鉴定到膳食多糖-肠道菌群-宿主互作机制解析的研究脉络，并系统梳理了团队在果胶等膳食纤维的研究进展。围绕近期发表于MRR的毛螺菌科菌株在IBS模型中的差异化作用研究，她重点探讨了下一代益生菌与活体生物药开发面临的挑战与机遇。同时，从“膳食成分→靶标菌株→功能验证"的全链条研究视角出发，她进一步分享了青年科研工作者如何在跨学科研究中找准切入点、构建系统性研究框架的经验思考，并结合长期科研实践，交流了科研工作者应具备的严谨性与“钉子精神”。

采访问题

Q1. 您能介绍一下您和团队目前的主要研究方向和研究重点吗？您最初是如何进入这一研究方向的？
Q2. 在您的研究中，不同膳食成分在影响肠道菌群和宿主健康方面似乎呈现出一些不同的作用特点。这一研究方向在领域内是如何逐渐受到关注并发展的？
Q3. 您在Microbiome Research Reports新发表的研究中比较了四株毛螺菌科菌株在IBS模型中的作用，发现它们虽然都能改善症状，但在代谢产物及作用通路上存在明显差异。这些结果对于未来精准益生菌或下一代活体生物治疗产品的开发有哪些启示？
Q4. 从膳食因素到特定菌群/菌株的功能研究，再到疾病模型中的验证，您觉得在这一整条研究链条中，最关键或者最有挑战性的环节是什么？
Q5. 在您长期的科研过程中，是否有一些经验或体会可以分享给大家？

点击观看完整视频~

个人简介

博士，南昌大学食品学院特聘研究员、博士生导师，入选赣鄱俊才支持计划・高校领军人才培养项目青年领军人才，深耕食品科学与工程领域，聚焦肠道微生物与膳食营养交叉方向开展原创性研究。长期围绕膳食成分-肠道菌群-人体健康互作机制展开系统攻关，核心研究包括三大板块：膳食活性组分对肠道菌群及宿主健康的调控机理、健康人群肠道功能菌种资源挖掘与开发、肠道微生物生理代谢与功能特性解析，聚焦天然来源的果胶等膳食纤维，探索新一代益生菌与精准营养应用路径。以第一/通讯作者发表高水平学术论文20篇，成果刊登于FEMS Microbiology Reviews, Trends in Food Science & Technology, Gut Microbes 等微生物、食品领域一区TOP国际顶刊，单篇最高IF达16.408；多篇成果选为期刊封面文章，同步产出中文核心期刊研究论文，研究体系兼具国际前沿性与产业应用价值。获批主持国家自然科学基金面上及青年基金项目、江西省科技合作专项重点项目、中国博士后科学基金特别资助、江西省自然科学基金青年基金等科研项目，参与国家重点研发计划课题1项（子课题主持）、国家自然科学基金重大项目1项。累计获授权国家发明专利10件、美国发明专利2件，为功能性食品、肠道益生菌产业化开发提供自主知识产权支撑。

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  1. CONNECT:[ UseTime:0.000484s ] mysql:host=127.0.0.1;port=3306;dbname=aa460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000751s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000302s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000341s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000590s ]
  6. SELECT * FROM `set` [ RunTime:0.000270s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000716s ]
  8. SELECT * FROM `article` WHERE `id` = 535329 LIMIT 1 [ RunTime:0.000414s ]
  9. UPDATE `article` SET `lasttime` = 1782795527 WHERE `id` = 535329 [ RunTime:0.014398s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.003614s ]
  11. SELECT * FROM `article` WHERE `id` < 535329 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000604s ]
  12. SELECT * FROM `article` WHERE `id` > 535329 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000413s ]
  13. SELECT * FROM `article` WHERE `id` < 535329 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000711s ]
  14. SELECT * FROM `article` WHERE `id` < 535329 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.009440s ]
  15. SELECT * FROM `article` WHERE `id` < 535329 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.001051s ]
0.104899s