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国自然资助!南昌大学第二附属医院的论文被质疑图片疑似重复

  • 2026-02-13 09:13:23
国自然资助!南昌大学第二附属医院的论文被质疑图片疑似重复

2022年9月，一项源自南昌大学第二附属医院的研究在知名期刊《Oncology Letters》（IF 2.2 / 4区）上崭露锋芒。然而，论文发表约3年后，国际学术讨论平台PubPeer上便出现了针对此项研究的质疑。有读者指出，文中部分实验图片存异常，具体表现为：关键图片疑似组内重复。需要指出的是，此项研究曾获得国家自然科学基金资助（项目编号：81760458）的支持。

论文质疑

这篇论文探讨了一个颇具吸引力的命题：miR55903p inhibits the proliferation and metastasis of renal cancer cells by targeting ROCK2 to inhibit proliferation, migration and invasion（miR - 5590 - 3p通过靶向ROCK2抑制肾癌细胞增殖、迁移和侵袭，从而抑制肾癌细胞的增殖和转移）

第一作者：南昌大学第二附属医院的Queling Liu

通讯作者：南昌大学第二附属医院的Zhengdong Hong

针对肾细胞癌领域中长期存在的问题，研究团队报告了积极的成果，miR - 5590 - 3p在RCC中下调。miR - 5590 - 3p过表达导致ROCK2和β - catenin下调，抑制RCC细胞的增殖、迁移和侵袭。双荧光素酶报告试验证实了miR - 5590 - 3p和ROCK2之间的结合关系。值得注意的是，ROCK2的过表达有效地逆转了miR - 5590 - 3p对RCC细胞的调节作用。综上所述，miR - 5590 - 3p通过靶向ROCK2抑制RCC细胞的增殖、迁移和侵袭，是RCC潜在的分子生物标志物和治疗靶点。

疑点与图片证据

目前，该论文在PubPeer等公开学术平台上受到3项质疑，主要指向实验图片疑似重复使用的问题。

疑点一：2026年1月，在学术圈公开评议平台Pubpeer上，学术调查者Sholto David指出，该图存在明显的局部图像重叠问题，这直接影响了其所呈现数据的独立性与可靠性。（见同色方框标记）

图4C

疑点二：继首轮质疑之后，同一位学术调查者在PubPeer上进一步指出，本文图1D的面板存在明显的局部图像重叠问题，这为质疑增添了关键性的证据链条。（见同色方框标记）

图1D

疑点三：同一位学术调查者在PubPeer上进一步指出，本文图3D和图4E的面板存在明显的局部图像重叠问题，这为质疑增添了关键性的证据链条。（见同色方框标记）

图3D和图4E

作者后续回复

针对所提出的质疑，截止于2026年1月28日，未见到作者在www.pubpeer.com上的回应内容。

参考信息来源：

https://pubpeer.com/publications/D3DA3A6F119583321CF2A74C271859/

https://www.spandidos-publications.com/10.3892/ol.2022.13497

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  1. CONNECT:[ UseTime:0.000580s ] mysql:host=127.0.0.1;port=3306;dbname=aa460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000563s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000252s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000281s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000479s ]
  6. SELECT * FROM `set` [ RunTime:0.000202s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000574s ]
  8. SELECT * FROM `article` WHERE `id` = 466619 LIMIT 1 [ RunTime:0.000933s ]
  9. UPDATE `article` SET `lasttime` = 1771010484 WHERE `id` = 466619 [ RunTime:0.003524s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 64 LIMIT 1 [ RunTime:0.000231s ]
  11. SELECT * FROM `article` WHERE `id` < 466619 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000378s ]
  12. SELECT * FROM `article` WHERE `id` > 466619 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000386s ]
  13. SELECT * FROM `article` WHERE `id` < 466619 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000698s ]
  14. SELECT * FROM `article` WHERE `id` < 466619 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001562s ]
  15. SELECT * FROM `article` WHERE `id` < 466619 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.002717s ]
0.080899s